Mahiro Oyama, a recluse and hopeless NEET, wakes up one day to find that he has turned into a “girl”! Confused by the beautiful girl reflected in the mirror, Mahiro learns from his genius younger sister, Mihari Oyama, who has advanced to college at an early age, that he had been drugged with a suspicious substance in his drink! After two years of staying indoors and indulging in questionable games, it’s time for him to get to work! As Mihari conducts observations on the effects of the “girl transformation drug,” Mahiro suddenly finds himself living as a girl, faced with the many unknowns of “girl life” such as using the toilet, taking baths, wearing skirts, and bras. Furthermore, he becomes acquainted with Kaede Hozuki, a classmate of Mihari’s from middle school, and her younger sister, Momiji, leading to a lively daily life for Mahiro. With a series of challenges ahead, what will become of the “former” big brother...?